Because we don't enter the fasted state until 12 hours after our last meal, it's rare that our bodies are in this fat burning state. This is one of the reasons why many people who start intermittent fasting will lose fat without changing what they eat, how much they eat, or how often they exercise. Fasting puts your body in a fat burning state that you rarely make it to during a normal eating schedule.
Another type of intermittent fasting, alternate day fasting has you severely restricting the amount of calories you eat during fasting days, then eating to your stomach’s content on non-fasting days. Food isn’t completely off the table, but you’ll stick to about 25 percent of your normal caloric intake. Someone eating 2,000 calories would cut back to 500, for example. Alternate-day fasting isn’t necessarily a long-term plan, because it can become difficult to stick to, but it can be helpful to get a healthy habit in motion.
By the 21st century, although fasting clearly was applicable in some instances of disease, such as in certain acute diseases (particularly when accompanied by a loss of appetite), whether fasting in other instances was beneficial to human health remained unclear. For example, whereas research in humans had suggested that intermittent fasting carried out over 15 days improved insulin-mediated glucose uptake into tissues, studies in rodents had indicated that such fasting, carried out over the long-term, promoted glucose intolerance and the release of damaging oxidants from tissues.